Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1905883 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2006 | 13 Pages |
Abstract
In complex diseases like ALS, there are multiple genetic and environmental factors all contributing to disease liability. The genetic factors causing susceptibility to developing ALS can be considered a spectrum from single genes with large effect sizes causing classical Mendelian ALS, to genes of smaller effect, producing apparently sporadic disease. We examine the statistical genetic principles that underpin this model and review what is known about ALS as a disease with complex genetics.
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Authors
Claire L. Simpson, Ammar Al-Chalabi,