Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1906027 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2006 | 5 Pages |
Abstract
This report describes the first biosynthetic analysis of the cystic fibrosis transmembrane conductance regulator (CFTR) in freshly excised human rectal biopsies. Expression of functional CFTR was assessed by intestinal current measurement (ICM) prior to biosynthetic studies. Several structural features of CFTR are found to be comparable to those established in CFTR-expressing cell lines. Interestingly, maturation of CFTR increases substantially in tissue incubated at 26 °C. Our data provide a solid basis for future studies on the characterisation of CFTR in pathological cases.
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Authors
Andrea van Barneveld, Frauke Stanke, Manfred Ballmann, Hassan Y. Naim, Burkhard Tümmler,