| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1906083 | Experimental Gerontology | 2016 | 5 Pages |
•The myocardium is characterized by limited regenerative capacity.•FSTL1 is an epicardial cardiogenic factor with dynamic expression after injury.•The rejuvenating effects can be mediated by blood-borne ‘pro-youthful’ factors.•Several growth hormone responses affect multiple signalling cascades.
The mechanisms of aging and senescence include various endogenous and exogenous factors. Among cardiovascular diseases, heart failure is a typical age-related disease. New strategies to restore cardiomyocyte cells have been reported: endogenous substances that can regenerate the heart's cardiomyocytes have been described: follistatin like 1 (FSTL1), growth-differentiation factor 11 (GDF11) and insulin-like growth factor 1 (IGF-I). Manipulation of the different anti and pro- pathways is essential to discover new approaches to regenerative therapies.
