| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1908547 | Free Radical Biology and Medicine | 2012 | 11 Pages |
Abstract
⺠Staphylococcus aureus pneumonia induces alveolar mitochondrial biogenesis in mice. Nrf2â/â mice show impaired lung mitochondrial biogenesis compared to WT mice. ⺠Type II cells are a main site of Nrf2-regulated alveolar mitochondrial biogenesis. ⺠Nrf2â/â mice have low type II cell anti-inflammatory IL-10 and SOCS3 responses. ⺠Nrf2 links alveolar mitochondrial biogenesis to local IL-10 and SOCS3 synthesis.
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Authors
Janhavi Athale, Allison Ulrich, Nancy Chou MacGarvey, Raquel R. Bartz, Karen E. Welty-Wolf, Hagir B. Suliman, Claude A. Piantadosi,