| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1908548 | Free Radical Biology and Medicine | 2012 | 12 Pages |
Abstract
⺠Oxidative stress induced by maternal diabetes is associated with heart malformations. ⺠Zn supplement restores the antioxidant system in the heart of embryos from diabetic mice. ⺠MT up-regulation protects hearts of embryos from Zn-supplemented diabetic mice. ⺠Zn supplement alters some trace elements in the embryonic heart of diabetic mice. ⺠Zn may be beneficial in prevention of diabetes-induced cardiac malformations in embryos.
Keywords
MDAOFTSTZTBARSGSSGGPXGSHROSAntioxidantIronstreptozotocinOxidative stressEmbryosMaternal diabetesSODSeleniumH9c2 cellsSuperoxide dismutasePhosphorusZincHeartthiobarbituric acid-reactive substancemalondialdehydeMetallothioneinCopperOutflow tractManganeseMagnesiumMiceNuclear microscopyCardiac malformationsNitric oxidereduced glutathioneCalciumEndocardial cushionoxidized glutathioneglutathione peroxidaseReactive oxygen species
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Authors
Srinivasan Dinesh Kumar, Murugaiyan Vijaya, Ramar Perumal Samy, S. Thameem Dheen, Minqin Ren, Frank Watt, Y. James Kang, Boon-Huat Bay, Samuel Sam Wah Tay,