| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1908681 | Free Radical Biology and Medicine | 2012 | 13 Pages |
Abstract
⺠We discovered two new copper-based cytotoxic agents. ⺠These agents target DNA through noncovalent binding modes. ⺠They induce double-strand DNA breaks in cisplatin-resistant cancer cells. ⺠These compounds generate intracellular reactive oxygen species in cancer cells. ⺠Cytotoxicity is linked to the induction of double-strand DNA breaks.
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Authors
Andrew Kellett, Orla Howe, Mark O'Connor, Malachy McCann, Bernadette S. Creaven, Siobhán McClean, Agnieszka Foltyn-Arfa Kia, Alan Casey, Michael Devereux,