| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1908838 | Free Radical Biology and Medicine | 2012 | 8 Pages |
Abstract
⺠Reactive oxygen species production by fatty acid β-oxidation is poorly characterized. ⺠Human electron-transfer flavoprotein produces both superoxide and hydrogen peroxide. ⺠Superoxide generation is dependent on the concentration of its partner dehydrogenase. ⺠Protein:protein interactions modulate the production of reactive oxygen species. ⺠Disease mutants show higher production of reactive oxygen species.
Keywords
ubiquinone oxidoreductaseMCADMADDAMPETFflavin adenine dinucleotideHRPSORHydrogen peroxideadenosine monophosphateFADProtein foldingOxidative stressFree radicalsMedium-chain acyl-CoA dehydrogenaseSODSuperoxideSuperoxide reductaseSuperoxide dismutaseFlavoproteinelectron transfer flavoproteinMitochondriaReduction potentialHorseradish peroxidaseOxidation–reductionMultiple acyl-CoA dehydrogenase deficiencyReactive oxygen species
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Authors
João V. Rodrigues, Cláudio M. Gomes,