Article ID Journal Published Year Pages File Type
1908847 Free Radical Biology and Medicine 2012 7 Pages PDF
Abstract
► Glycochenodeoxycholate (GCDC) induced alveolar epithelial (AECII) death in vitro. ► Oxidative stress and mitochondrial damage were detected in GCDC-treated AECII. ► Reactive oxygen species (ROS) scavengers and caspase inhibitors rescued cell death. ► Rat AECII surfactant secretion was inhibited by glycochenodeoxycholate.
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