| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1908863 | Free Radical Biology and Medicine | 2012 | 11 Pages |
Abstract
⺠We studied the effects of exogenous H2O2 on phenotype and functions of human pDCs. ⺠Human pDCs are more sensitive to oxidative stress induced by H2O2 than conventional DCs. ⺠Exposure to a low concentration of H2O2 did not activate pDCs. ⺠The presence of H2O2 inhibits activation of pDCs triggered by TLR7-mediated signals. ⺠Human pDCs exposed to oxidative stress in vivo may have an anti-inflammatory role.
Keywords
FCSinducible costimulator ligand7-AADELISPOTTLRNACPDL-1mAbPBMCH2DCFDAROSMonoclonal antibodyinflammationEnzyme-linked immunospotinterferonIFNOxidative stressToll-like receptorFree radicalsfetal calf serumPeripheral blood mononuclear cellDendritic cellHelper T cellplasmacytoid dendritic cellsProgrammed death ligand 1Immune regulationReactive oxygen species
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Authors
Kitti Pazmandi, Zoltan Magyarics, Istvan Boldogh, Aniko Csillag, Eva Rajnavolgyi, Attila Bacsi,