| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1908895 | Free Radical Biology and Medicine | 2011 | 9 Pages |
Abstract
⺠Cytomegalovirus (CMV) infection impairs arteriolar dilation. ⺠This is mediated by blood cell- and vessel wall- associated NAD(P)H oxidases. ⺠CMV and hypercholesterolemia synergize to induce venular blood cell recruitment. ⺠Platelet and vascular NAD(P)H oxidases mediate the thrombogenic phenotype. ⺠eNOS dysfunction underlies both the leukocyte and platelet adhesion in these venules.
Keywords
Murine CMVL-NNANG-nitro-l-arginineMCMVMicrovasculatureeNOStetrahydrobiopterinBH4NAD(P)H oxidaseO2•−ROSAChAcetylcholinecardiovascular diseaseFree radicalsHigh-cholesterol dietnormal dietendothelial nitric oxide synthaseSuperoxidecytomegalovirusCMVCytomegalovirus infectionwild typePlatelet adhesionReactive oxygen species
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Authors
Igor L. Leskov, Jennifer Whitsett, Jeannette Vasquez-Vivar, Karen Y. Stokes,