| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1908913 | Free Radical Biology and Medicine | 2011 | 7 Pages |
Abstract
⺠We examined the effects of low-level CYP3A4 expression in HepG2 cells. ⺠CYP3A4 increased reactive oxygen levels in the cells. ⺠CYP3A4 altered the secretion of cancer-associated autocrine and paracrine factors. ⺠An antioxidant suppressed intracellular ROS levels and changes in protein secretion. ⺠An NFκB inhibitor suppressed secretion of platelet-derived growth factor (PDGF).
Keywords
NAINF-κBMMP2CYP2E1HepG2CYP3A4PDGFNACAMRCD14Cyclophilin AICAM1ParacrineP450N-acetylcysteineROSamphiregulinAutocrineSecretionFree radicalscytochrome P450 2E1cytochrome P450 3A4Cytochrome P450endoplasmic reticulumVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factornuclear factor κBintracellular adhesion molecule 1
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Authors
Richard C. Zangar, Nikki Bollinger, Thomas J. Weber, Ruimin M. Tan, L. Meng Markillie, Norman J. Karin,