| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1908931 | Free Radical Biology and Medicine | 2012 | 5 Pages |
Abstract
⺠Cu metabolism is deranged in the cortex in Alzheimer's disease (AD). ⺠Alzheimer affected cortex contains an increased fraction of exchangeable copper ions. ⺠Alzheimer cortex has an increased capacity to coordinate Cu in the reactive cupric state. ⺠The increased exchangeable Cu in AD cortex is associated with increased oxidation.
Keywords
PBSCBMNFTET-AASTriethylenetetramineTBARSIMACROSAlzheimer diseaseOxidative stressTETANeurofibrillary tangleFree radicalsBCselectrothermal atomic absorption spectroscopyinductively coupled plasma mass spectrometryICP-MSCortexPhosphate-buffered salineCerebellumCopperBrodmann areathiobarbituric acid-reactive substancesMetal homeostasisImmobilized metal-affinity chromatographySoluble fractionReactive oxygen species
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Authors
Simon A. James, Irene Volitakis, Paul A. Adlard, James A. Duce, Colin L. Masters, Robert A. Cherny, Ashley I. Bush,