Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1910738 | Free Radical Biology and Medicine | 2009 | 12 Pages |
Abstract
The influence of a variety of microenvironmental factors on the inherent reactivity of membrane-located reagents is poorly understood. A goal of this review is to provide detailed profiles of membrane properties, including hydrophobicity, oxygen and nitric oxide solubility and diffusion rates, bilayer penetration of metal ions and metal-ion complexes, and membrane order and fluidity, that can be obtained with EPR spin-labeling methods. These properties can drastically vary with membrane composition, membrane depth, and membrane domain formation, influencing the fate of chemical reactions that occur in a lipid bilayer environment.
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Authors
Witold K. Subczynski, Justyna Widomska, Jimmy B. Feix,