Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1910797 | Free Radical Biology and Medicine | 2008 | 11 Pages |
Abstract
The visible light-induced phototoxicity of titanium dioxide modified with platinum(IV) chloride complexes, [TiO2/PtCl4], was tested. In vitro experiments with the mouse melanoma cells (S-91) have demonstrated phototoxicity of the [TiO2/PtCl4] material. Detection of efficiently generated various reactive oxygen species (·OH, O2·−, H2O2, 1O2) and also reactive chlorine species has proven the photodynamic activity of the tested material, induced by visible light (λ > 455 nm). The cellular death (recognized as a necrosis) is a result of the cell membrane peroxidation.
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Authors
Agnieszka Jańczyk, Agnieszka Wolnicka-Głubisz, Krystyna Urbanska, Horst Kisch, Grażyna Stochel, Wojciech Macyk,