Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1910813 | Free Radical Biology and Medicine | 2008 | 8 Pages |
Abstract
Within the last two decades, 4-hydroxynonenal has emerged as an important second messenger involved in the regulation of various cellular processes. Our recent studies suggest that HNE can induce apoptosis in various cells through the death receptor Fas (CD95)-mediated extrinsic pathway as well as through the p53-dependent intrinsic pathway. Interestingly, through its interaction with the nuclear protein Daxx, HNE can self-limit its apoptotic role by translocating Daxx to cytoplasm where it binds to Fas and inhibits Fas-mediated apoptosis. In this paper, after briefly describing recent studies on various biological activities of HNE, based on its interactions with Fas, Daxx, and p53, we speculate on possible mechanisms through which HNE may affect a multitude of cellular processes and draw a parallel between signaling roles of H2O2 and HNE.
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Authors
Yogesh C. Awasthi, Rajendra Sharma, Abha Sharma, Sushma Yadav, Sharad S. Singhal, Pankaj Chaudhary, Sanjay Awasthi,