Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1911889 | Free Radical Biology and Medicine | 2006 | 10 Pages |
Abstract
The airway mucosal epithelium is the first site of virus contact with the host, and the main site of infection and inflammation. Nitric oxide (NO) produced by the airway epithelium is vital to antiviral inflammatory and immune defense in the lung. Multiple mechanisms function coordinately to support high-level basal NO synthesis in healthy airway epithelium and further induction of NO synthesis in the infected airway of normal hosts. Hosts deficient in NO synthesis, such as those patients with cystic fibrosis, have impaired antiviral defense and may benefit from therapies to augment NO levels in the airways.
Keywords
ssRNApoly(IC)LPOHRSVIRFdsRNAPKRS-nitrosoglutathioneGSNOcGMPEPOHOClNOSGSHMPOguanosine 3′,5′-cyclic monophosphateNO2−NO3−O2−ONOO−single-stranded RNAdouble-stranded RNAROSHydrogen peroxideSTATeosinophil peroxidasehypochlorous acidBALFNitric oxide synthasesSuperoxideCMVcytomegalovirusinterferon regulatory factorCystic fibrosisBronchoalveolar lavage fluidSignal transducer and activator of transcriptionmyeloperoxidaseNitrateNitriteNitric oxideH2O2human respiratory syncytial virusHIVhuman immunodeficiency virusHuman parainfluenza virusesPeroxynitritepolyinosinic-polycytidylic acidreduced glutathioneGasReactive oxygen species
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Authors
Weiling Xu, Shuo Zheng, Raed A. Dweik, Serpil C. Erzurum,