Article ID Journal Published Year Pages File Type
1916318 Journal of the Neurological Sciences 2007 4 Pages PDF
Abstract

Previous validation studies on the PDQ-8, a brief disease-specific quality of life instrument, were performed with the PDQ-8 nested in the original PDQ-39. Such an approach may influence patient responses and the psychometric properties of the PDQ-8. We therefore undertook this study to validate the PDQ-8 when administered independently in English and Chinese and found good item-to-scale correlations (correlation coefficient: 0.44–0.68) and internal consistency (Cronbach's alpha: 0.81, 0.87). Factor analyses yielded a component on which all 8 questions were substantially loaded (loading range: 0.55–0.77). Scree plots also showed the one-factor solution thereby validating the PDQ-8 summary index. Construct validation against the Hoehn and Yahr stage and UPDRS motor scores showed significant correlations between higher PDQ-8 summary index and increased disease severity in both English and Chinese versions. Our results show the PDQ-8 to be a valid and reliable disease-specific HRQoL instrument for PD when used independently of the PDQ-39.

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