Primary ovarian insufficiency: Relation to changes in body composition and adiposity

There are several causes of primary ovarian insufficiency (POI) but all result in a premature cessation of female reproductive potential, mimicking the normal menopause. In normal menopause, there is increased cardiovascular risk associated with changes in body composition (specifically increasing adiposity). We sought to review the literature on POI in relation to changes in adiposity and related cardiometabolic risk factors. We conclude that POI patients are usually less obese than reference groups.