Article ID Journal Published Year Pages File Type
1918829 Maturitas 2007 8 Pages PDF
Abstract

ObjectiveTo compare the effectiveness of tibolone and 17β-estradiol on climacteric symptoms, in a randomized, single-blind, cross-over study in surgically menopausal women.Material and methodsForty surgically menopausal women were divided randomly into two groups. Group A received treatment with tibolone for 6 months, while group B received 17β-estradiol. After 3 weeks washout period, treatment protocols were exchanged for another 6 months. The climacteric symptoms were assessed with Greene Climacteric Scale at baseline, during washout and after the treatments. Statistical analysis was done with the Wilcoxon's Sign Rank test.ResultsBoth treatments significantly improved the scores of all subscales with respect to baseline. However, the improvement in psychological, somatic and sexual subscales were significantly superior in the tibolone group compared with 17β-estradiol group. Both treatments showed comparable improvements in the relief of vasomotor symptoms.ConclusionOur findings suggest that tibolone may improve mood, libido and somatic symptoms in surgically menopausal women to a greater extent than estrogen therapy alone.

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Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
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