Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1919105 | Maturitas | 2006 | 8 Pages |
Abstract
The effect of a 6 week-treatment with the AT1 receptor antagonist candesartan (16Â mg/d) on endothelium-dependent vasorelaxation was compared to the treatment with placebo or the calcium channel antagonist felodipine (5Â mg/d) in 29 postmenopausal women in the absence or presence of hormone replacement therapy (HRT) in a prospective, double-blind, randomized cross-over study. Endothelial function was assessed by measurement of forearm blood flow (FBF) by venous occlusion plethysmography. FBF during reactive hyperemia was significantly improved by candesartan in patients without HRT (hyperemic peak flow and area under the FBF curve), whereas felodipine and placebo exerted no effect. In patients with HRT, no treatment regimen showed a significant effect on endothelial function. Nitroglycerin-induced vasorelaxation and basal FBF were not significantly altered in all groups. AT1 receptor antagonism improves vascular function in postmenopausal women without HRT. Thus, AT1 receptor blockade may resemble an efficient approach for the prevention of vascular dysfunction in estrogen-deficient women.
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Authors
Kerstin Wassmann, Ardeshir Ghiassi, Sven Wassmann, Michael Böhm, Georg Nickenig,