Association of the Laminin, Alpha 5 (LAMA5) rs4925386 with height and longevity in an elderly population from Southern Italy

We tested additional SNPs within the LAMA5 gene for association with anthropometric traits and longevity in our cohort of elderly subjects (N = 624). Under an additive model, the rs2427283-C allele (P = 0.02) and the rs4925386-T allele (P = 0.01) were associated with shorter stature. Age-stratified analyses showed that the rs4925386-T allele was also positively associated with longevity (P = 0.001). The association of LAMA5 rs4925386 alleles with both inter-individual differences in height and in longevity suggests that laminins may be among the factors linking stature and cancer susceptibility.