| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1919237 | Mechanisms of Ageing and Development | 2012 | 7 Pages |
Abstract
⺠p16Ink4a status from tumorigenic or non-tumorigenic cells escaping from senescence. ⺠Overexpression of p21Waf1/Cip1 demethylated p16Ink4a and restored cellular senescence. ⺠p16Ink4a and adjacent genes are deleted in non-tumorigenic immortalized cells. ⺠The functional loss of p16Ink4aper se might not be sufficient for tumorigenesis. ⺠The data shed light on the strategy of anti-aging by regulating p16Ink4a expression.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Xiaoming Wu, Shuting Jia, Xiufeng Zhang, Xiaoyu Si, Wenru Tang, Ying Luo,