| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1919429 | Mechanisms of Ageing and Development | 2010 | 12 Pages |
Abstract
Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Sadie L. Hebert, Ian R. Lanza, K. Sreekumaran Nair,