Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1919458 | Mechanisms of Ageing and Development | 2009 | 4 Pages |
Abstract
The gene expression profiles of lysophosphatidic acid (LPA)-treated young and senescent human diploid fibroblasts (HDFs) were examined using cDNA microarray analysis. The expression of some genes, including EGR 1/3 and MRRF, was controlled by LPA similarly in young and senescent cells, showing a typical time-dependent up-and-down expression profile. In contrast, some other genes, including DUSP6, CYR61, and F3, showed sustained upregulation in senescent HDFs later after LPA treatment. These genes might be involved in altered LPA responsiveness during the aging process.
Keywords
Related Topics
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Ji-Heon Rhim, Ik-Soon Jang, Jong-Soon Choi, Hyun Jin Kwon, Eui-Ju Yeo, Sang Chul Park,