| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1919815 | Mechanisms of Ageing and Development | 2006 | 4 Pages |
Abstract
Immortal SVts8 cells that express thermolabile SV40 T antigen exhibit a senescence-like phenomenon upon inactivation of the T antigen. By using a cDNA subtractive hybridization technique, RAB27B, a member of the RAB GTPase family, was found to be up-regulated in senescent SVts8 cells. The up-regulation of RAB27B depends on the p53 gene. Enhanced expression was also observed in replicative senescence in normal human fibroblasts.
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Authors
Michihiko Fujii, Yoshinori Kawai, Morio Endoh, Mohammad Nazir Hossain, Kazuhiko Nakabayashi, Dai Ayusawa,