Le fibroblaste sénescent : un catalyseur de la tumorigenèse

At first, cell senescence can be considered as a suppressive mechanism in cancer initiation. However, aging as a main risk factor in carcinoma development, is characterized by an increase in senescent fibroblasts exhibiting an inflammatory phenotype: “inflamm-aging” in several tissues. Senescent fibroblasts secretome is actively involved in tumor progression as favoring epithelio-mesenchymal transition, angiogenesis and chemotaxis of inflammatory cells. Notably, tumor microenvironment contains a myriad of proteolytic enzymes generating “Matrikines” able to accelerate the invasiveness of tumor cells. The presence of senescent fibroblasts might therefore constitute a niche for tumor development and a therapeutic approach targeted to those cells or/and secretory molecules has been proposed.