Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1921284 | Parkinsonism & Related Disorders | 2009 | 4 Pages |
Abstract
We evaluated the neurological and neuropsychological profiles and olfaction as presymptomatic markers in a large family with Parkinson disease (PD) caused by the G2019S mutation in the LRRK2 gene. Five affected family members, 14 asymptomatic mutation carriers and 15 non-carriers were compared. Patients had typical dopa-responsive PD, frequently associated with cognitive impairment. Asymptomatic carriers and non-carriers could not be distinguished because of their neuropsychological status, the presence of depression or olfactory impairment. We were therefore unable to identify a presymptomatic marker of LRRK2-related PD.
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Authors
Ebba Lohmann, Laurence Leclere, Francesca De Anna, Suzanne Lesage, Bruno Dubois, Yves Agid, Alexandra Dürr, Alexis Brice,