Auditory event-related potentials in Parkinson's disease: Prominent correlation with attention

Objective: Auditory P300 has been reported to be abnormal in demented patients with Parkinson's disease. However, it is still controversial which factors in Parkinson's disease influence P300 parameters.Methods: Forty patients with Parkinson's disease were included. Patients were divided into two groups: patients with dementia (PDD) and without dementia (PDND). An ‘odd-ball’ paradigm was used for auditory event-related potentials.Results: P300 latency was markedly delayed in PDD patients. Age and DRS1 (attention) were the most important factors influencing P300 latency.Conclusions: Although there have been reports of P300 in the past, its abnormalities reflect the deficit of attention in Parkinson's disease.