Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1921483 | Parkinsonism & Related Disorders | 2008 | 5 Pages |
Abstract
Variants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson's disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson's disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson's disease in any of our four patient-control series (n = 2373). Taken together our results do not support a role for Omi/HtrA2 variants in the pathogenesis of Parkinson's disease.
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Authors
Owen A. Ross, Alexandra I. Soto, Carles Vilariño-Güell, Michael G. Heckman, Nancy N. Diehl, Mary M. Hulihan, Jan O. Aasly, Sigrid Sando, J. Mark Gibson, Timothy Lynch, Anna Krygowska-Wajs, Grzegorz Opala, Maria Barcikowska, Krzysztof Czyzewski,