Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1921484 | Parkinsonism & Related Disorders | 2008 | 4 Pages |
Abstract
A single nucleotide polymorphism in the promoter region of the dopamine β-hydroxylase gene (DBH â1021C > T; rs1611115) is reported to regulate plasma enzyme activity levels. This variant has also been the focus of two large association studies in Parkinson's disease yielding conflicting results. We examined this association in four Caucasian patient-control series (n = 2696). A modest protective association was observed in the Norwegian series (OR = 0.81, p = 0.03; n = 1676), however, the effect was in the opposite direction in the Polish series (OR = 2.01, p = 0.01; n = 224). No association was observed for DBH â1021C > T with disease susceptibility in the US and Irish series, or combining all four series (OR = 0.91, p = 0.16, n = 2696). We observed a modest association between DBH â1021C > T and AAO in the combined series (p = 0.01). Taken together, these findings indicate that DBH â1021C > T does not play a major role in the pathogenesis of Parkinson's disease.
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Authors
Owen A. Ross, Michael G. Heckman, Alexandra I. Soto, Nancy N. Diehl, Kristoffer Haugarvoll, Carles Vilariño-Güell, Jan O. Aasly, Sigrid Sando, J. Mark Gibson, Timothy Lynch, Anna Krygowska-Wajs, Grzegorz Opala, Maria Barcikowska, Krzysztof Czyzewski,