| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1921917 | Parkinsonism & Related Disorders | 2008 | 5 Pages |
Abstract
ObjectiveTo study delayed failure after subthalamic nucleus (STN) deep brain stimulation in Parkinson's disease (PD) patients.MethodsOut of 56 consecutive bilaterally STN-implanted PD patients, we selected subjects who, after initial clinical improvement (⩾1 month after surgery), lost benefit (delayed failure, DF).ResultsFive patients developed sub-acutely severe gait disorders (DF). In 4/5 DF patients, a micro-lesion effect, defined as improvement without stimulation, was observed; immediate post-operative MRI demonstrated electrode located above or behind to the STN.ConclusionsPatients presenting micro-lesion effect should be carefully monitored, as this phenomenon can mask electrodes misplacement and evolution in DF.
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Authors
C. Granziera, C. Pollo, H. Russmann, C. Staedler, J. Ghika, J.-G. Villemure, P.R. Burkhard, F.J.G. Vingerhoets,