Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1922124 | Parkinsonism & Related Disorders | 2007 | 4 Pages |
Abstract
Familiar Parkinson's disease has an age of onset from the second to the sixth decade, whereas Wilson's disease (WD) usually presents in the first decade of life. We studied three sisters with a form of very-late-onset major depression and parkinsonism with probable linkage to ATP7B gene. Molecular studies demonstrated a nucleotide deletion at the 5â²UTR region in a single allele of ATP7B gene. They did not have a family history of WD, or markers indicative for copper deposition in peripheral tissues. We suggest that single allele mutations of ATP7B gene may confer a susceptibility for late-onset major depression and parkinsonism.
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Authors
GianPietro Sechi, Giovanni Antonio Cocco, Alessandra Errigo, Luca Deiana, Giulio Rosati, Virgilio Agnetti, Kay Stephen Paulus, Giovanni Mario Pes,