Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1922533 | Parkinsonism & Related Disorders | 2007 | 4 Pages |
Abstract
White matter lesions (WML) and epilepsy have been occasionally seen in Wilson's disease. No cases of generalized myoclonus have been reported so far. We present a patient with psychiatric symptoms starting at age 16, followed by tremor, generalized dystonia and severe generalized myoclonus. In addition to classical findings, the MRI showed also extensive WML in temporal, parietal and frontal regions, preserving interhemispheric fibers. Necropsy revealed marked alterations of white matter, cortex and basal ganglia. We subsequently review the literature concerning WML and myoclonus in Wilson's disease.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Egberto Reis Barbosa, Laura Silveira-Moriyama, Alexandre Costa Machado, Luiz Alberto Bacheschi, Sérgio Rosemberg, Milberto Scaff,