Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1922769 | Parkinsonism & Related Disorders | 2006 | 7 Pages |
Abstract
We observed a mutation frequency of 8.5% in Parkin gene among Indian PD patients based on sequencing and gene dosage analysis of its exons. We identified nine point mutations of which seven are novel and hitherto unreported. These mutations accounted for 14.3% familial PD, 6.9% young onset and 5.9% late onset sporadic PD. Of the 20 PD patients with mutations only two had homozygous mutations and one was a compound heterozygote. Homozygous exonic deletions were absent but heterozygous exon rearrangements were observed in 9.2% of patients (19% familial PD and 4.5% young onset sporadic PD).
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Authors
Shashi Chaudhary, Madhuri Behari, Maninder Dihana, Pazhayannur V. Swaminath, Shyla T. Govindappa, Sachi Jayaram, Vinay Goyal, Arindam Maitra, Uday B. Muthane, R.C. Juyal, B.K. Thelma,