| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1923247 | Redox Biology | 2013 | 10 Pages |
Abstract
⺠HO-1KO has worsened lung structure after hyperoxia and in room air recovery. ⺠Protein synthesis is inhibited and cell cycle gene expression is dysregulated in the KO. ⺠In the WT neonatal lung, HO-1 protein localizes to the nucleus in hyperoxia. ⺠HO-1 interacts with hnRNPK in vitro and in vivo. ⺠This modulates protein synthesis and gene expression explaining lung abnormalities.
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Authors
Guang Yang, Chhanda Biswasa, Qing Sara Lin, Ping La, Fumihiko Namba, Tiangang Zhuang, Manasa Muthu, Phyllis A. Dennery,