Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
192657 | Electrochimica Acta | 2008 | 6 Pages |
Abstract
Electrochemically induced catalytic tandem Knoevenagel–Michael reaction of 3-methyl-2-pyrazolin-5-ones, aryl aldehydes and malononitrile or alkyl cyanoacetates in alcohols in an undivided cell in the presence of sodium bromide as an electrolyte results in the formation of substituted 3-(5-hydroxy-3-methylpyrazol-4-yl)-3-arylpropionitriles in 75–97% yields. The developed efficient electrocatalytic approach to the corresponding 3-(5-hydroxy-3-methylpyrazol-4-yl)-3-arylpropionitriles is beneficial from the viewpoint of diversity-oriented large-scale processes and represents novel, facile and environmentally benign synthetic concept for multicomponent reactions strategy.
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Authors
Michail N. Elinson, Alexander S. Dorofeev, Ruslan F. Nasybullin, Sergey K. Feducovich, Gennady I. Nikishin,