Combinatorial micro electrochemistry: Part 1. Automated micro electrosynthesis of iminoquinol ether and [1,2,4]triazolo[4,3-a]pyridinium perchlorate collections in the wells of microtiter plates

A computer-controlled instrument, based on scanning electrochemical microscope technology, is employed in the miniaturized combinatorial electrosynthesis of localized compound collections. Libraries of iminoquinol ethers and triazolo-pyridinium ions are generated in the wells of microtiter plates by potentiostatic electrolysis. Several experimental protocols are described and implemented. Progress of the electrolyses is monitored by microelectrode steady-state voltammetry and product formation is screened by HPLC/MS.