Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
197434 | Electrochimica Acta | 2005 | 8 Pages |
Abstract
A simple electrochemical synthesis of β-lactams has been developed using constant current electrolysis in a suitable solvent-supporting electrolyte solutions, with subsequent addition of bromoamides. The regio- and stereo-selectivity of the electrochemically-induced cyclization of bromoamides to β-lactams, via NC4 bond formation, has been evidenced. This synthesis avoids any addition of bases and probases and gives β-lactams in high yields.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
M. Feroci, M. Orsini, L. Palombi, L. Rossi, A. Inesi,