| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 202105 | Fluid Phase Equilibria | 2011 | 4 Pages |
The solubility of Deflazacort in four solvents, acetone, ethyl acetate, ethanol and 2-propanol, was measured at temperatures ranging from 293.15 K to 348.15 K at atmospheric pressure using Laser Monitoring Technique. The solubility data were correlated by the modified Apelblat model. Then the dissolution enthalpy and entropy of Deflazacort were predicted from the solubility data using van’t Hoff equation. In this study, it should be concluded that the viscosity and surface tension of solvents affect the solubility behavior, dissolution enthalpy and entropy of Deflazacort in different solvents.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► We determine the solubility of Deflazacort in four solvents. ► The dissolution enthalpy and entropy of Deflazacort are calculated. ► The solubility increases with increasing temperature. ► The dissolution enthalpy and entropy are much higher in alcoholic solvents.
