Thermodynamic solubility of pioglitazone HCl in polyethylene glycols 200, 400 or 600 + water mixtures at 303.2 and 308.2 K—Data report and modeling

•Measuring solubility of pioglitazone HCl in aqueous binary mixtures of PEGs 200, 400 and 600 at 298.2 to 308.2 K.•Modeling with three kind of cosolvency models: Three different cosolvency models; yalkowsky, Jouyban–Acree and combined version of the Jouyban–Acree model with van’t Hoff approach.•Comparing the produced error percentages with whole three models.•Using the trained version for predicting the solubility data.

The solubility of pioglitazone HCl (99 data points) in binary mixtures of polyethylen glycols (PEGs) 200, 400 or 600 + water at three different temperatures which ranged from 298.2 K to 308.2 K were reported. Three different cosolvency models; yalkowsky, Jouyban–Acree and combined version of the Jouyban–Acree model with van’t Hoff approach, have been used for correlating the reported data, and the correlation OMRDs are 65.2%, 18.0% and 17.8% respectively. Also, a previously trained version of the Jouyban–Acree model has been used for predicting these 99 reported data points which the prediction OMRD is 23.4%.