Association between serum 25-hydroxyvitamin D concentrations and prevalence of metabolic syndrome

PurposeThere is now good evidence that 25-hydroxyvitamin D (25OHD) status may have an important impact on the development and progression of cardiovascular disease. Because of the potential involvement of vitamin D deficiency in blood pressure control and immune responses, we aimed to investigate whether there was a relationship between 25OHD status and the prevalence of metabolic syndrome in an Iranian population.Material/methodsThe study was carried out on a sample of 846 subjects [357(42.19%) males and 489(57.80%) females], derived from MASHAD STUDY. Serum 25OHD levels were measured using a competitive electroluminescence protein binding assay. Anthropometric indices were measured using standard protocols.ResultsSerum 25OHD was 12.7 (6.8–18.4) ng/ml in the metabolic syndrome (MetS) group and 14.1 (8.8–19.0) ng/ml in the group without metabolic syndrome (P = 0.43). The frequency of vitamin D deficiency was 80.7% and 79.0% in subjects with or without metabolic syndrome in Iranian population.ConclusionsWe found no significant difference in serum 25OHD concentrations between individuals with or without MetS and no significant linear relationship between serum 25OHD and several CVD risk factors.