Oral administration of leaf extracts of Momordica charantia affect reproductive hormones of adult female Wistar rats

ABSTRACTObjectiveTo determine the effect of graded doses of aqueous leaf extracts of Momordica charantia on fertility hormones of female albino rats.MethodsTwenty adult, healthy, female Wistar rats were divided into four groups: low dose (LD), moderate dose (MD) and high dose (HD) groups which received 12.5 g, 25.0 g, 50.0 g of the leaf extract respectively and control group that was given with water ad libatum.ResultEstrogen levels reduced by 6.40 nmol/L, 10.80 nmol/L and 28.00 nmol/L in the LD, MD and HD groups respectively while plasma progesterone of rats in the LD, MD and HD groups reduced by 24.20 nmol/L, 40.8 nmol/L and 59.20 nmol/L respectively.ConclusionOur study has shown that the antifertility effect of Momordica charantia is achieved in a dose dependent manner. Hence, cautious use of such medication should be advocated especially when managing couples for infertility.