Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2033369 | Asian Pacific Journal of Tropical Biomedicine | 2012 | 6 Pages |
Abstract
In our findings, isolated lobeline (20mg/kg) exhibited potent anticonvulsant activity against PTZ induced seizures. Also a biochemical evaluation suggested significant increase in barain GABA level at 20 mg/kg i.p. of isolated lobeline. Hence, we may propose that lobeline reduces epileptic seizures by enhancing the GABA release supporting the GABAergic mechanism.
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Authors
Abrar M Tamboli, Rukhsana A Rub, Pinaki Ghosh, SL Bodhankar,