Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
203345 | Fluid Phase Equilibria | 2013 | 7 Pages |
•This study investigates solubilities of etodolac and enhancements of them by adding co-solvents.•Six cyclodextrins (CDs): α, β, γ-CD, 2-HP-β-CD, 2-HE-β-CD, and M-β-CD were investigated as co-solvent.•Solubilities of etodolac containing water/co-solvent mixtures were measured using HPLC at 298 K.•The solubilization power and stability constant for five co-solvents were evaluated.•It can be concluded that chemically modified CDs are more suitable co-solvents than natural CDs.
The purpose of this study is to measure the solubilities of poorly water-soluble drugs, and to enhance their solubilities by adding co-solvents. Etodolac, a cyclooxygenase-2 (cox-2) inhibitor in non-steroid anti-inflammatory drugs (NSAIDs), was selected as a model pharmaceutical compound. The solubilities of etodolac were determined at 298.15 K in mixtures of water and the following six cyclodextrins (CDs) using high-performance liquid chromatography: α-CD, β-CD, γ-CD, 2-hydroxypropyl-β-CD, 2-hydroxyethyl-β-CD, and methyl-β-CD. With the exception of γ-CD, the experimental solubility data were correlated using a modified Chrastil model. Additionally, the solubilization power of each correlated co-solvent–solute system was evaluated using a log-linear model. Finally, the stability constants were determined using the Takeru Higuchi–Connors solubility method.