| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2035201 | Cell | 2015 | 15 Pages |
•Wnt ligands promote YAP/TAZ activation via the alternative Wnt signaling pathway•Alternative Wnt-YAP/TAZ signaling consists of Wnt-FZD/ROR-Gα12/13-Rho-Lats1/2-YAP/TAZ•YAP/TAZ mediate alternative Wnt signaling-induced osteogenesis and cell migration•YAP/TAZ antagonize Wnt/β-catenin signaling by inducing secreted Wnt inhibitors
SummaryThe transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contributes to human cancer. Here, we discover YAP/TAZ as bona fide downstream effectors of the alternative Wnt signaling pathway. Wnt5a/b and Wnt3a induce YAP/TAZ activation independent of canonical Wnt/β-catenin signaling. Mechanistically, we delineate the “alternative Wnt-YAP/TAZ signaling axis” that consists of Wnt-FZD/ROR-Gα12/13-Rho GTPases-Lats1/2 to promote YAP/TAZ activation and TEAD-mediated transcription. YAP/TAZ mediate the biological functions of alternative Wnt signaling, including gene expression, osteogenic differentiation, cell migration, and antagonism of Wnt/β-catenin signaling. Together, our work establishes YAP/TAZ as critical mediators of alternative Wnt signaling.
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