Frodos Found: Behold the CENP-A “Ring” Bearers

CENP-A is a histone H3-like protein specific to centromeres that is essential for kinetochore formation and accurate chromosome segregation in eukaryotes. Recent studies (Dunleavy et al., 2009, Foltz et al., 2009, Perpelescu et al., 2009, Pidoux et al., 2009 and Williams et al., 2009) analyze CENP-A binding proteins required for the recruitment of CENP-A to centromeres in humans and in fission yeast, bringing us closer to understanding how centromere identity is faithfully propagated.