| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2037497 | Cell | 2008 | 5 Pages |
Abstract
In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-renewal while continually presenting opportunities for lineage specification.
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Authors
Jose Silva, Austin Smith,