Solubilities of rutin in eight solvents at T = 283.15, 298.15, 313.15, 323.15, and 333.15 K

The solubilities of rutin in water, methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, acetone, and ethyl acetate were determined at T = 283.15, 298.15, 313.15, 323.15, and 333.15 K using RP-HPLC. The solubilities of rutin in pure solvents increase with increasing temperature except ethyl acetate. A simplified thermodynamic equation and an empirical equation were used to correlate the experimental data. These data of solubility can be used to purify the reaction mixture system.