Proteins Kinases: Chromatin-Associated Enzymes?

Protein kinases contribute to the regulation of gene expression by interacting with transcription factors that are recruited to the regulatory regions of genes. Previous studies investigated the role of protein kinases in transcription initiation. Here, we discuss new insights gleaned from recent work showing that kinases can also interact with chromatin throughout the entire transcribed region of target genes (Pokholok et al., 2006 and Proft et al., 2006).