FOXP3 and NFAT: Partners in Tolerance

Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell ( Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional regulators FOXP3 and NFAT.